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Protein Engineering: Techniques and Applications
Bentley University, Waltham
Tuesday, May 19, 2009
| 8:00-9:00am |
Check-in and light breakfast |
| 9:00-9:05am |
Opening Remarks, Marc Jacobs, Vertex Pharmaceuticals |
| Session I: Engineering for affinity and specificity (Session chair: Laura
Silvian) |
| 9:05-10:00am |
Synthetic Antibodies: New Tools for New Biology
Sachdev Sidhu, University of Toronto, Toronto, Canada |
| 10:00-10:35am |
Engineered Variant of Human Artemin with Reduced Heparin Sulfate Binding has Improved Pharmaceutical Properties
Anthony Rossomando, Biogen Idec, Cambridge, MA |
| 10:35-10:55am |
Coffee break and poster session |
| 10:55-11:50am |
Design and construction of a highly functional, non-random, synthetic
pre-immune antibody repertoire
Dane Wittrup, Adimab, Inc., Lebanon, NH |
| 11:50-12:40pm |
Lunch |
| Session II: Alternative scaffolds (Session chair: Ben
Hackel) |
| 12:40-1:35pm |
Beyond Antibodies: Designer binding proteins using non-antibody scaffolds
Shohei Koide, University of Chicago, Chicago, IL |
| 1:35-2:05pm |
Dual Variable Domain Immunoglobulin (DVD-Ig)
Chengbin Wu, Abbott Bioresearch Center, Worcester, MA |
| 2:05-2:35pm |
The Evolution of Molecular Diversity in β-Bundles
Jessica Goodman, Schepartz Laboratory, Yale University |
| 2:35-3:00pm |
Coffee break and poster session |
| Session III: Ligands and enzyme engineering (Session chair: Joe Arndt) |
| 3:00-3:55pm |
Role of Electrostatics in Ligand Binding and Design
Bruce Tidor, Massachusetts Institute of Technology, Cambridge, MA |
| 3:55-4:25pm |
Quantitative Exploration of Catalytic Landscapes in Protein Evolution
Paul O'Maille, The Salk Institute for Biological Sciences, La Jolla, CA |
| 4:25-4:55pm |
Engineering enzyme substrate specificity using computational design of a defined-sequence library
Shaun Lippow, Codon Devices |
| 4:55pm-onward |
Mixer and poster session |
Speakers and posters
We would like to extend an invitation to scientists at all levels to share their experiences and present their
results. To accommodate for the proprietary nature of the talks we welcome proposals for the shorter talks which do
not uniquely identify the target protein. We are hoping that scientists will use shorter talks and poster sessions to
present the technical challenges of their work.
Similarly we invite posters which present interesting technical stories but do not necessarily identify the project.
If you are interesting in participating or would like to present in one of the sessions, please contact one of the
organizers:
NOTE: Registration is now closed. However, if you have not yet paid,
please use this link.
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