Designing Structure: Protein Therapeutics and Vaccines
Structure-based design has transformed vaccines and protein therapeutics, with cryo-EM data driving much of this impact.
Please join us to hear Jason McLellan discuss his flagship work on stabilizing viral fusion proteins such as RSV F and the SARS-CoV-2 spike in their prefusion conformations using rational mutations. You will also hear talks from companies such as Pfizer, Invivyd, and Generate:Biomedicines, which build on the same principles by using high-resolution structural data and machine-learning-driven protein design to engineer antigens and therapeutic proteins. These approaches optimize protein shape for potency, stability, and manufacturability, enabling a shift from relying on natural proteins to designing tailor-made three-dimensional scaffolds based on desired function.
The talks will present practical routes to faster and more precise vaccines and biologic drugs that can be tuned for emerging pathogens and complex diseases. We will also explore how these successful applications are setting the stage for the next exciting chapters in structure-based therapeutics.
Sponsors
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Previous Meetings
- Cryo-EM Symposium
- BIO-SAXS Symposia
- A workshop to focus on cryoEM
- A workshop to focus on BIO-SAXS applications in drug discovery
- Targeting RNA: Expanding Therapeutic Biology
- The Resolution Revolution in cryoEM: Potential for Drug Discovery
- Exploiting Genomic Instability in Cancer: DNA Damage and Immuno Oncology
- Future of Drug Delivery: Novel Approaches to Targeted Therapies
- Genome Engineering: Theory into Practice
- Hybrid Methods: The Evolution of Structural Biology
- Protein Misfolding and Rare Genetic Diseases: From Human Genetics to Drug Discovery
- Protein-Ligand Thermodynamics and Kinetics: Building bridges between in silico and biophysical realms
- Assaying Proteins in Solution: A workshop to focus on BIO-SAXS
- Epigenetics: Unwrapping the Future for Drug Discovery?
- Beyond the lattice: A Renaissance In Structural Biology
- Celebrating 50 Years of Crystallography
- Protein Engineering: Techniques and Applications
- New Techniques in Protein Sciences - developments in protein science for biopharma and drug discovery
- Infectious Disease and Drug Discovery Meeting
- Overcoming the Challenges to Accelerate Drug Discovery
- Membrane Proteins: Structure and Function
- Protein Kinases and Drug Discovery
- Systems Biology in Drug Discovery