Designing Structure: Protein Therapeutics and Vaccines
|
Structure-based design has transformed vaccines and protein therapeutics, with cryo-EM data driving much of this impact.
Please join us to hear Jason McLellan discuss his flagship work on stabilizing viral fusion proteins such as RSV F and the SARS-CoV-2 spike in their prefusion conformations using rational mutations. You will also hear talks from companies such as Pfizer, Invivyd, and Generate:Biomedicines, which build on the same principles by using high-resolution structural data and machine-learning-driven protein design to engineer antigens and therapeutic proteins. These approaches optimize protein shape for potency, stability, and manufacturability, enabling a shift from relying on natural proteins to designing tailor-made three-dimensional scaffolds based on desired function.
The talks will present practical routes to faster and more precise vaccines and biologic drugs that can be tuned for emerging pathogens and complex diseases. We will also explore how these successful applications are setting the stage for the next exciting chapters in structure-based therapeutics.
Register nowThere is a small fee for attending. Students and others please contact info@nesba.net for tickets. Sponsors
|
Friday, April 10, 2026 Registration and Coffee: Agenda: Mixer: 3:30 - 6:00 PM Meeting locationSanofi
|
The New England Structural Biology Association (NESBA) is a non-profit organization, run by volunteers. We are dedicated to bringing together industrial scientists with the shared vision of using protein structure to enable the design of novel therapeutics. NESBA disciplines include: Protein Sciences; X-ray Crystallography; NMR; Molecular Modeling; Biology; Chemistry; Computational Chemistry; and Electron Microscopy.